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Tocris Bioscience™ Forskolin

Adenylyl cyclase activator

Overview
135.20 GBP valid until 2025-07-30
Use promo code "24078" to get your promotional price.

Additional Details:
Additional Details: CAS Number: 66575-29-9 Weight: 0.00970kg


Quantity 10 mg

Product Code. 18782764

Quantity Price
1 £ 169.0 / 10mg
In stock, ready to ship: 33
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Description and Specification

Chemical Identifiers

CAS 66575-29-9
Molecular Formula C22H34O7
Molecular Weight (g/mol)
InChI Key
Synonym
PubChem CID
ChEBI
IUPAC Name
SMILES

Specification

Chemical Name or Material (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
CAS 66575-29-9
Quantity 10 mg
Molecular Formula C22H34O7
Formula Weight 410.51
Purity >98%
Molecular Weight (g/mol) 410.507

Forskolin, or coleonol, is a cell-permeable, potent, reversible and rapid activator of adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate (EC50 = 0.5 μM). In combination with 5 other compounds, forskolin enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent stem cells, without genetic factors: Valproic acid, sodium salt (Cat. No. 2815), RepSox (Cat. No. 3742), Tranylcypromine hydrochloride (Cat. No. 3852), CHIR 99021 (Cat. No. 4423) and 3-Deazaneplanocin A hydrochloride (Cat. No. 4703). In combination with IBMX (Cat. No. 2845), forskolin induces neural differentiation of mesenchymal stem cells by downregulating neuron restrictive silencer factor. In a rat model of Huntington's disease-like neurodegeneration, forskolin also exhibits neuroprotective effects. Hypotensive and vasodilatory agent.

Water-soluble analog, NKH 477 (Cat. No. 1603), and Forskolin synthesized to Ancillary Material Grade also available.

For more information about how Forskolin may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons.

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